Cargando…

Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1α/miR210/ISCU Axis Activation

Nickel and its compounds, which are well-documented carcinogens, induce the Warburg effect in normal cells by stabilizing hypoxia-inducible factor 1α (HIF-1α). Melatonin has shown diverse anticancer properties for its reactive oxygen species- (ROS-) scavenging ability. Our aim was to explore how mel...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Mindi, Zhou, Chao, Lu, Yonghui, Mao, Ling, Xi, Yu, Mei, Xiang, Wang, Xue, Zhang, Lei, Yu, Zhengping, Zhou, Zhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275958/ https://www.ncbi.nlm.nih.gov/pubmed/32566089 http://dx.doi.org/10.1155/2020/5406284

Ejemplares similares

Quercetin Antagonizes Glucose Fluctuation Induced Renal Injury by Inhibiting Aerobic Glycolysis via HIF-1α/miR-210/ISCU/FeS Pathway
por: Xu, Wei-long, et al.
Publicado: (2021)

New insights into the pathology of pulmonary hypertension: implication of the miR-210/ISCU1/2/Fe-S axis
por: Tang, Haiyang, et al.
Publicado: (2015)

MitoKATP regulating HIF/miR210/ISCU signaling axis and formation of a positive feedback loop in chronic hypoxia-induced PAH rat model
por: Lu, Yang, et al.
Publicado: (2017)

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension
por: White, Kevin, et al.
Publicado: (2015)

MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron–sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells
por: He, M, et al.
Publicado: (2014)

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin
por: Pi, Huifeng, et al.
Publicado: (2015)

Clinically relevant HIF-1α-dependent metabolic reprogramming in oropharyngeal squamous cell carcinomas includes coordinated activation of CAIX and the miR-210/ISCU signaling axis, but not MCT1 and MCT4 upregulation
por: Sáenz-de-Santa-María, Inés, et al.
Publicado: (2017)

Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis
por: Li, Qingguo, et al.
Publicado: (2018)

miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis
por: McCormick, R I, et al.
Publicado: (2013)

Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin
por: Yu, Changhui, et al.
Publicado: (2022)

ISCU(M108I) and ISCU(D39V) Differ from Wild-Type ISCU in Their Failure To Form Cysteine Desulfurase Complexes Containing Both Frataxin and Ferredoxin
por: Cai, Kai, et al.
Publicado: (2018)

N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization
por: Freibert, Sven-A., et al.
Publicado: (2021)

The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
por: Wang, Jing‐Zi, et al.
Publicado: (2021)

Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production
por: Ullmann, Pit, et al.
Publicado: (2016)

Potential role of HIF-1-responsive microRNA210/HIF3 axis on gemcitabine resistance in cholangiocarcinoma cells
por: Silakit, Runglawan, et al.
Publicado: (2018)

EDDM3A drives gastric cancer progression by promoting HIF-1α-dependent aerobic glycolysis
por: Wu, Tao, et al.
Publicado: (2022)

Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells
por: Woo, Yu Mi, et al.
Publicado: (2015)

TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer
por: Xiang, Jinfeng, et al.
Publicado: (2018)

MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU
por: Favaro, Elena, et al.
Publicado: (2010)

The Complex Energy Landscape of the Protein IscU
por: Bothe, Jameson R., et al.
Publicado: (2015)

S1P/S1PR3 axis promotes aerobic glycolysis by YAP/c-MYC/PGAM1 axis in osteosarcoma
por: Shen, Yifei, et al.
Publicado: (2018)

LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-α pathway in retinoblastoma
por: Song, Kun, et al.
Publicado: (2021)

NNMT promotes the progression of intrahepatic cholangiocarcinoma by regulating aerobic glycolysis via the EGFR-STAT3 axis
por: Lu, Shounan, et al.
Publicado: (2022)

NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma
por: Su, Xiangsheng, et al.
Publicado: (2021)

NOX4-derived ROS Regulates Aerobic Glycolysis of Breast Cancer through YAP Pathway
por: Zhang, Zhenzhen, et al.
Publicado: (2023)

Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited
por: Vazquez, Alexei, et al.
Publicado: (2010)

Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF
por: Cheng, Jiao, et al.
Publicado: (2019)

Regulation of iron homeostasis by the p53-ISCU pathway
por: Funauchi, Yuki, et al.
Publicado: (2015)

Melatonin Improves Waterlogging Tolerance of Malus baccata (Linn.) Borkh. Seedlings by Maintaining Aerobic Respiration, Photosynthesis and ROS Migration
por: Zheng, Xiaodong, et al.
Publicado: (2017)

Targeting Aerobic Glycolysis and HIF-1α Expression Enhance Imiquimod-induced Apoptosis in Cancer Cells
por: Huang, Shi-Wei, et al.
Publicado: (2014)

MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation
por: Liu, L, et al.
Publicado: (2016)

MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation
por: Liu, L, et al.
Publicado: (2017)

Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro
por: Guo, Pan, et al.
Publicado: (2014)

FOXO3a-SIRT6 axis suppresses aerobic glycolysis in melanoma
por: Dong, Zhen, et al.
Publicado: (2020)

ISCU interacts with NFU1, and ISCU[4Fe-4S] transfers its Fe-S cluster to NFU1 leading to the production of holo-NFU1
por: Cai, Kai, et al.
Publicado: (2020)

Aerobic Glycolysis: Beyond Proliferation
por: Jones, William, et al.
Publicado: (2015)

Oncogenic virus-induced aerobic glycolysis and tumorigenesis
por: Yu, Li, et al.
Publicado: (2018)

PRKAR2B‐HIF‐1α loop promotes aerobic glycolysis and tumour growth in prostate cancer
por: Xia, Lei, et al.
Publicado: (2020)

SIPA1 Enhances Aerobic Glycolysis Through HIF-2α Pathway to Promote Breast Cancer Metastasis
por: Yao, Chenguang, et al.
Publicado: (2022)

NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling
por: Ma, Shuaijun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lhc5d8fh69v2n86bill8luuudi