Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn’s disease

Angiotensin-Converting Enzyme 2 (ACE2) has been identified as the host receptor for SARS-coronavirus 2 (SARS-CoV-2) which has infected millions world-wide and likely caused hundreds of thousands of deaths. Utilizing transcriptomic data from four cohorts taken from Crohn’s disease (CD) and non-inflam...

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Detalles Bibliográficos
Autores principales: Potdar, Alka A., Dube, Shishir, Naito, Takeo, Botwin, Gregory, Haritunians, Talin, Li, Dalin, Yang, Shaohong, Bilsborough, Janine, Denson, Lee A., Daly, Mark, Targan, Stephan R., Fleshner, Phillip, Braun, Jonathan, Kugathasan, Subra, Stappenbeck, Thaddeus S., McGovern, Dermot P.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276052/
https://www.ncbi.nlm.nih.gov/pubmed/32511625
http://dx.doi.org/10.1101/2020.04.19.20070995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276052/
https://www.ncbi.nlm.nih.gov/pubmed/32511625
http://dx.doi.org/10.1101/2020.04.19.20070995

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