Extra-adrenal glucocorticoid biosynthesis: Implications for autoimmune and inflammatory disorders.

Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here its side chain is cleaved by CYP11A1 producing pregnenolone. Pregnenolone is converted to cortisol by the enzymes 3-βHSD...

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Detalles Bibliográficos
Autores principales: Slominski, Radomir, Tuckey, Robert C., Manna, Pulak R., Jetten, Anton M., Postlethwaite, Arnold, Raman, Chander, Slominski, Andrzej T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276297/
https://www.ncbi.nlm.nih.gov/pubmed/32203088
http://dx.doi.org/10.1038/s41435-020-0096-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276297/
https://www.ncbi.nlm.nih.gov/pubmed/32203088
http://dx.doi.org/10.1038/s41435-020-0096-6

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