Inhibition of human immunodeficiency virus type 1 by niclosamide through mTORC1 inhibition

Niclosamide has been known to inhibit a number of pH-dependent viruses via the neutralization of endosomal acidic pH. It has also been shown to disrupt the mTORC1 signaling pathway. The replication of many viruses requires mTORC1 activation. Here, we investigated the inhibitory activity of niclosami...

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Detalles Bibliográficos
Autores principales: Niyomdecha, Nattamon, Suptawiwat, Ornpreya, Boonarkart, Chompunuch, Jitobaom, Kunlakunya, Auewarakul, Prasert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276449/
https://www.ncbi.nlm.nih.gov/pubmed/32529067
http://dx.doi.org/10.1016/j.heliyon.2020.e04050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276449/
https://www.ncbi.nlm.nih.gov/pubmed/32529067
http://dx.doi.org/10.1016/j.heliyon.2020.e04050

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