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Absolute quantitative analysis of intact and oxidized amino acids by LC-MS without prior derivatization

The precise characterization and quantification of oxidative protein damage is a significant challenge due to the low abundance, large variety, and heterogeneity of modifications. Mass spectrometry (MS)-based techniques at the peptide level (proteomics) provide a detailed but limited picture due to...

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Detalles Bibliográficos
Autores principales: Gamon, Luke F., Guo, Chaorui, He, Jianfei, Hägglund, Per, Hawkins, Clare L., Davies, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276450/
https://www.ncbi.nlm.nih.gov/pubmed/32505089
http://dx.doi.org/10.1016/j.redox.2020.101586