Characterization of organic anion transporting polypeptide 1b2 knockout rats generated by CRISPR/Cas9: a novel model for drug transport and hyperbilirubinemia disease

Organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1/3) as important uptake transporters play a fundamental role in the transportation of exogenous drugs and endogenous substances into cells. Rat OATP1B2, encoded by the Slco1b2 gene, is homologous to human OATP1B1/3. Although OATP1B1/3 is ver...

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Detalles Bibliográficos
Autores principales: Ma, Xinrun, Shang, Xuyang, Qin, Xuan, Lu, Jian, Liu, Mingyao, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276679/
https://www.ncbi.nlm.nih.gov/pubmed/32528832
http://dx.doi.org/10.1016/j.apsb.2019.11.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276679/
https://www.ncbi.nlm.nih.gov/pubmed/32528832
http://dx.doi.org/10.1016/j.apsb.2019.11.007

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