WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling

Diabetic nephropathy (DN) is a chronic diabetic microvascular complication. Hyperactivity of the polyol pathway is involved in the pathogenesis of DN. Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, is expected to be an effective target in the treatment of DN. WJ-39 is a novel...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaoyu, Liu, Zheng, Ying, Ke, Wang, Huimin, Liu, Peng, Ji, Xuefei, Chi, Tianyan, Zou, Libo, Wang, Shaojie, He, Zhonggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277034/
https://www.ncbi.nlm.nih.gov/pubmed/32566101
http://dx.doi.org/10.1155/2020/7950457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277034/
https://www.ncbi.nlm.nih.gov/pubmed/32566101
http://dx.doi.org/10.1155/2020/7950457

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