Novel Barbiturate-Nitrate Compounds Inhibit the Upregulation of Matrix Metalloproteinase-9 Gene Expression in Intestinal Inflammation through a cGMP-Mediated Pathway

Matrix metalloproteinase-9 is upregulated in inflammatory bowel disease. Barbiturate nitrate hybrid compounds have been designed to inhibit MMP secretion and enzyme activity. In this study, we investigated the mechanism of action of barbiturate-nitrate hybrid compounds and their component parts usin...

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Detalles Bibliográficos
Autores principales: O’Sullivan, Shane, Wang, Jun, Radomski, Marek W., Gilmer, John F., Medina, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277209/
https://www.ncbi.nlm.nih.gov/pubmed/32466182
http://dx.doi.org/10.3390/biom10050808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277209/
https://www.ncbi.nlm.nih.gov/pubmed/32466182
http://dx.doi.org/10.3390/biom10050808

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