Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors

Boronic acid transition-state analog inhibitors (BATSIs) are partners with β-lactam antibiotics for the treatment of complex bacterial infections. Herein, microbiological, biochemical, and structural findings on four BATSIs with the FOX-4 cephamycinase, a class C β-lactamase that rapidly hydrolyzes...

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Detalles Bibliográficos
Autores principales: Lefurgy, Scott T., Caselli, Emilia, Taracila, Magdalena A., Malashkevich, Vladimir N., Biju, Beena, Papp-Wallace, Krisztina M., Bonanno, Jeffrey B., Prati, Fabio, Almo, Steven C., Bonomo, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277225/
https://www.ncbi.nlm.nih.gov/pubmed/32349291
http://dx.doi.org/10.3390/biom10050671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277225/
https://www.ncbi.nlm.nih.gov/pubmed/32349291
http://dx.doi.org/10.3390/biom10050671

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