The Minimal Effect of Linker Length for Fatty Acid Conjugation to a Small Protein on the Serum Half-Life Extension

Conjugation of serum albumin or one of its ligands (such as fatty acid) has been an effective strategy to prolong the serum half-lives of drugs via neonatal Fc receptor (FcRn)–mediated recycling of albumin. So far, fatty acid (FA) has been effective in prolonging the serum half-lives for therapeutic...

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Detalles Bibliográficos
Autores principales: Cho, Jinhwan, Park, Junyong, Tae, Giyoong, Jin, Mi Sun, Kwon, Inchan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277390/
https://www.ncbi.nlm.nih.gov/pubmed/32357510
http://dx.doi.org/10.3390/biomedicines8050096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277390/
https://www.ncbi.nlm.nih.gov/pubmed/32357510
http://dx.doi.org/10.3390/biomedicines8050096

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