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Metformin: Sentinel of the Epigenetic Landscapes That Underlie Cell Fate and Identity
The biguanide metformin is the first drug to be tested as a gerotherapeutic in the clinical trial TAME (Targeting Aging with Metformin). The current consensus is that metformin exerts indirect pleiotropy on core metabolic hallmarks of aging, such as the insulin/insulin-like growth factor 1 and AMP-a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277648/ https://www.ncbi.nlm.nih.gov/pubmed/32443566 http://dx.doi.org/10.3390/biom10050780 |