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The Antitumor Agent Ansamitocin P-3 Binds to Cell Division Protein FtsZ in Actinosynnema pretiosum

Ansamitocin P-3 (AP-3) is an important antitumor agent. The antitumor activity of AP-3 is a result of its affinity towards β-tubulin in eukaryotic cells. In this study, in order to improve AP-3 production, the reason for severe growth inhibition of the AP-3 producing strain Actinosynnema pretiosum W...

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Detalles Bibliográficos
Autores principales: Wang, Xinran, Wang, Rufan, Kang, Qianjin, Bai, Linquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277737/
https://www.ncbi.nlm.nih.gov/pubmed/32365857
http://dx.doi.org/10.3390/biom10050699