Upregulation of Sortilin, a Lysosomal Sorting Receptor, Corresponds with Reduced Bioavailability of Latent TGFβ in Mucolipidosis II Cells

Mucolipidosis II (ML-II) is a lysosomal disease caused by defects in the carbohydrate-dependent sorting of soluble hydrolases to lysosomes. Altered growth factor signaling has been identified as a contributor to the phenotypes associated with ML-II and other lysosomal disorders but an understanding...

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Detalles Bibliográficos
Autores principales: Barnes, Jarrod W., Aarnio-Peterson, Megan, Norris, Joy, Haskins, Mark, Flanagan-Steet, Heather, Steet, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277838/
https://www.ncbi.nlm.nih.gov/pubmed/32357547
http://dx.doi.org/10.3390/biom10050670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277838/
https://www.ncbi.nlm.nih.gov/pubmed/32357547
http://dx.doi.org/10.3390/biom10050670

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