Cargando…
Hemistepsin A Inhibits Cell Proliferation and Induces G0/G1-Phase Arrest, Cellular Senescence and Apoptosis Via the AMPK and p53/p21 Signals in Human Hepatocellular Carcinoma
Hemistepsin A (HsA), a natural sesquiterpene lactone isolated from Hemistepta lyrata, has been known as a wide range of anti-tumor effects. The aim of this study was to determine whether HsA suppresses hepatocellular carcinoma (HCC) and to figure out the cellular signaling pathways involved in the a...
Autores principales: | Baek, Su Youn, Hwang, Ui Wook, Suk, Ho Young, Kim, Young Woo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277854/ https://www.ncbi.nlm.nih.gov/pubmed/32375410 http://dx.doi.org/10.3390/biom10050713 |
Ejemplares similares
-
AMPK Activity Contributes to G2 Arrest and DNA Damage Decrease via p53/p21 Pathways in Oxidatively Damaged Mouse Zygotes
por: He, Pei, et al.
Publicado: (2020) -
Cooperation between p21 and Akt is required for p53‐dependent cellular senescence
por: Kim, Young Yeon, et al.
Publicado: (2017) -
Downregulation of Pim-2 induces cell cycle arrest in the G(0)/G(1) phase via the p53-non-dependent p21 signaling pathway
por: Liu, Zhaoyun, et al.
Publicado: (2018) -
Inhibition of Autophagy Promotes Hemistepsin A-Induced Apoptosis via Reactive Oxygen Species-Mediated AMPK-Dependent Signaling in Human Prostate Cancer Cells
por: Kim, Kwang-Youn, et al.
Publicado: (2021) -
Hemistepsin A inhibits T0901317-induced lipogenesis in the liver
por: Kim, Jae Kwang, et al.
Publicado: (2021)