New Insights into Key Determinants for Adenosine 1 Receptor Antagonists Selectivity Using Supervised Molecular Dynamics Simulations

Adenosine receptors (ARs), like many otherGprotein-coupledreceptors (GPCRs), are targets of primary interest indrug design. However, one of the main limits for the development of drugs for this class of GPCRs is the complex selectivity profile usually displayed by ligands. Numerous efforts have been...

Descripción completa

Detalles Bibliográficos
Autores principales: Bolcato, Giovanni, Bissaro, Maicol, Deganutti, Giuseppe, Sturlese, Mattia, Moro, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278174/
https://www.ncbi.nlm.nih.gov/pubmed/32392873
http://dx.doi.org/10.3390/biom10050732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278174/
https://www.ncbi.nlm.nih.gov/pubmed/32392873
http://dx.doi.org/10.3390/biom10050732

Ejemplares similares