A high‐affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

Maladaptive plasticity involving increased expression of AMPA‐type glutamate receptors is involved in several pathologies, including neuropathic pain, but direct inhibition of AMPARs is associated with side effects. As an alternative, we developed a cell‐permeable, high‐affinity (~2 nM) peptide inhi...

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Detalles Bibliográficos
Autores principales: Christensen, Nikolaj R, De Luca, Marta, Lever, Michael B, Richner, Mette, Hansen, Astrid B, Noes‐Holt, Gith, Jensen, Kathrine L, Rathje, Mette, Jensen, Dennis Bo, Erlendsson, Simon, Bartling, Christian RO, Ammendrup‐Johnsen, Ina, Pedersen, Sofie E, Schönauer, Michèle, Nissen, Klaus B, Midtgaard, Søren R, Teilum, Kaare, Arleth, Lise, Sørensen, Andreas T, Bach, Anders, Strømgaard, Kristian, Meehan, Claire F, Vægter, Christian B, Gether, Ulrik, Madsen, Kenneth L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278562/
https://www.ncbi.nlm.nih.gov/pubmed/32352640
http://dx.doi.org/10.15252/emmm.201911248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278562/
https://www.ncbi.nlm.nih.gov/pubmed/32352640
http://dx.doi.org/10.15252/emmm.201911248

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