Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells

Mitochondrial glutathione (mGSH) is critical for cell survival. We recently reported the localization of OGC (SLC25A11) and DIC (SLC25A10) in hRPE. Herein, we investigated the suppression of OGC and DIC and the effect of αB crystallin chaperone peptide co-treatment on RPE cell death and mitochondria...

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Detalles Bibliográficos
Autores principales: Sreekumar, Parameswaran G, Wang, Mo, Spee, Christine, Sadda, Srinivas R., Kannan, Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278883/
https://www.ncbi.nlm.nih.gov/pubmed/32408520
http://dx.doi.org/10.3390/antiox9050411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278883/
https://www.ncbi.nlm.nih.gov/pubmed/32408520
http://dx.doi.org/10.3390/antiox9050411

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