Cargando…

Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells

Mitochondrial glutathione (mGSH) is critical for cell survival. We recently reported the localization of OGC (SLC25A11) and DIC (SLC25A10) in hRPE. Herein, we investigated the suppression of OGC and DIC and the effect of αB crystallin chaperone peptide co-treatment on RPE cell death and mitochondria...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sreekumar, Parameswaran G, Wang, Mo, Spee, Christine, Sadda, Srinivas R., Kannan, Ram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278883/ https://www.ncbi.nlm.nih.gov/pubmed/32408520 http://dx.doi.org/10.3390/antiox9050411

Ejemplares similares

Mechanism of RPE Cell Death in α-Crystallin Deficient Mice: A Novel and Critical Role for MRP1-Mediated GSH Efflux
por: Sreekumar, Parameswaran G., et al.
Publicado: (2012)

Glutathione Metabolism and the Novel Role of Mitochondrial GSH in Retinal Degeneration
por: Sreekumar, Parameswaran G., et al.
Publicado: (2021)

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
por: Sreekumar, Parameswaran G., et al.
Publicado: (2016)

Characterization and Regulation of Carrier Proteins of Mitochondrial Glutathione Uptake in Human Retinal Pigment Epithelium Cells
por: Wang, Mo, et al.
Publicado: (2019)

Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells
por: Minasyan, Leonid, et al.
Publicado: (2017)

Oxidative Stress and Lipid Accumulation Augments Cell Death in LDLR-Deficient RPE Cells and Ldlr (−/−) Mice
por: Sreekumar, Parameswaran Gangadharan, et al.
Publicado: (2022)

Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione
por: Matsunaga, Douglas, et al.
Publicado: (2016)

Protection of Retina by αB Crystallin in Sodium Iodate Induced Retinal Degeneration
por: Zhou, Peng, et al.
Publicado: (2014)

Endoplasmic reticulum-mitochondrial crosstalk: a novel role for the mitochondrial peptide humanin
por: Sreekumar, Parameswaran G., et al.
Publicado: (2017)

Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice
por: Sreekumar, Parameswaran Gangadharan, et al.
Publicado: (2023)

Mechanisms of Epithelial-Mesenchymal Transition and Prevention of Dispase-Induced PVR by Delivery of an Antioxidant αB Crystallin Peptide †
por: Wada, Iori, et al.
Publicado: (2022)

αB Crystallin Is Apically Secreted within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells
por: Sreekumar, Parameswaran G., et al.
Publicado: (2010)

Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration
por: Sreekumar, Parameswaran G., et al.
Publicado: (2020)

GSH rescue by N-acetylcysteine
por: Ruffmann, R., et al.
Publicado: (1991)

Alantolactone Induces Apoptosis in HepG2 Cells through GSH Depletion, Inhibition of STAT3 Activation, and Mitochondrial Dysfunction
por: Khan, Muhammad, et al.
Publicado: (2013)

Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ
por: Widdrington, John D., et al.
Publicado: (2017)

Thiosemicarbazone p-Substituted Acetophenone Derivatives Promote the Loss of Mitochondrial Δψ, GSH Depletion, and Death in K562 Cells
por: Pessoto, Felipe S., et al.
Publicado: (2015)

Synergistic Activity of Ketoconazole and Miconazole with Prochloraz in Inducing Oxidative Stress, GSH Depletion, Mitochondrial Dysfunction, and Apoptosis in Mouse Sertoli TM4 Cells
por: Petricca, Sabrina, et al.
Publicado: (2022)

Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors
por: Brown, Emily E., et al.
Publicado: (2019)

PSCs Reveal PUFA-Provoked Mitochondrial Stress as a Central Node Potentiating RPE Degeneration in Bietti’s Crystalline Dystrophy
por: Zhang, Zhao, et al.
Publicado: (2020)

Functional re-evaluation of the putative glutathione transporters, RcGshT and RsGshT.
por: Li, L., et al.
Publicado: (1997)

A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration
por: Su, Feng, et al.
Publicado: (2019)

Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: Relevance to age-related macular degeneration
por: Sonoda, Shozo, et al.
Publicado: (2009)

Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis
por: Whitson, Jeremy A., et al.
Publicado: (2017)

GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer
por: Zhou, Zhanwei, et al.
Publicado: (2020)

Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletion
por: Zhou, Xiaoxiang, et al.
Publicado: (2022)

Depletion of Toxoplasma adenine nucleotide translocator leads to defects in mitochondrial morphology
por: Wu, Yihan, et al.
Publicado: (2022)

Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy
por: Toms, Maria, et al.
Publicado: (2019)

Changes in Mitochondrial Size and Morphology in the RPE and Photoreceptors of the Developing and Ageing Zebrafish
por: Burgoyne, Thomas, et al.
Publicado: (2022)

Short‐term control of diet affects cisplatin‐induced acute kidney injury through modulation of mitochondrial dynamics and mitochondrial GSH
por: Kim, Ji Su, et al.
Publicado: (2022)

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons
por: Guo, Lan, et al.
Publicado: (2013)

Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits
por: Zhou, Bing, et al.
Publicado: (2016)

Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion
por: Xu, Hongliang, et al.
Publicado: (2014)

Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase
por: Mailloux, Ryan J., et al.
Publicado: (2016)

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease
por: Torres, Sandra, et al.
Publicado: (2016)

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading
por: Baulies, Anna, et al.
Publicado: (2017)

Gold nanoclusters as a GSH activated mitochondrial targeting photosensitizer for efficient treatment of malignant tumors
por: Fan, Chen, et al.
Publicado: (2021)

A water-soluble fluorescent probe for monitoring mitochondrial GSH fluctuations during oxidative stress
por: Wang, Huayu, et al.
Publicado: (2022)

Antisense Oligonucleotide-Mediated Silencing of Mitochondrial Fusion and Fission Factors Modulates Mitochondrial Dynamics and Rescues Mitochondrial Dysfunction
por: Garcia, Daniel A., et al.
Publicado: (2022)

Activation of LXRs Reduces Oxysterol Lipotoxicity in RPE Cells by Promoting Mitochondrial Function
por: Xie, Lirong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mekokarn3nac4dn6qar2thfna6