Intronic Alternative Polyadenylation in the Middle of the DMD Gene Produces Half-Size N-Terminal Dystrophin with a Potential Implication of ECG Abnormalities of DMD Patients

The DMD gene is one of the largest human genes, being composed of 79 exons, and encodes dystrophin Dp427m which is deficient in Duchenne muscular dystrophy (DMD). In some DMD patient, however, small size dystrophin reacting with antibody to N-terminal but not to C-terminal has been identified. The m...

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Detalles Bibliográficos
Autores principales: Rani, Abdul Qawee Mahyoob, Yamamoto, Tetsushi, Kawaguchi, Tatsuya, Maeta, Kazuhiro, Awano, Hiroyuki, Nishio, Hisahide, Matsuo, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278912/
https://www.ncbi.nlm.nih.gov/pubmed/32443516
http://dx.doi.org/10.3390/ijms21103555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278912/
https://www.ncbi.nlm.nih.gov/pubmed/32443516
http://dx.doi.org/10.3390/ijms21103555

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