Novel 3′-Substituted-1′,2′,4′-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their O-Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo

A series of novel 18βH-glycyrrhetinic acid (GA) derivatives containing 3′-(alkyl/phenyl/pyridin(-2″, -3″, and -4″)-yl)-1′,2′,4′-oxadiazole moieties at the C-30 position were synthesized by condensation of triterpenoid’s carboxyl group with corresponding amidoximes and further cyclization. Screening...

Descripción completa

Detalles Bibliográficos
Autores principales: Markov, Andrey V., Sen’kova, Aleksandra V., Popadyuk, Irina I., Salomatina, Oksana V., Logashenko, Evgeniya B., Komarova, Nina I., Ilyina, Anna A., Salakhutdinov, Nariman F., Zenkova, Marina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279002/
https://www.ncbi.nlm.nih.gov/pubmed/32429154
http://dx.doi.org/10.3390/ijms21103511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279002/
https://www.ncbi.nlm.nih.gov/pubmed/32429154
http://dx.doi.org/10.3390/ijms21103511

Ejemplares similares