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Novel 3′-Substituted-1′,2′,4′-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their O-Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo

A series of novel 18βH-glycyrrhetinic acid (GA) derivatives containing 3′-(alkyl/phenyl/pyridin(-2″, -3″, and -4″)-yl)-1′,2′,4′-oxadiazole moieties at the C-30 position were synthesized by condensation of triterpenoid’s carboxyl group with corresponding amidoximes and further cyclization. Screening...

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Detalles Bibliográficos
Autores principales:	Markov, Andrey V., Sen’kova, Aleksandra V., Popadyuk, Irina I., Salomatina, Oksana V., Logashenko, Evgeniya B., Komarova, Nina I., Ilyina, Anna A., Salakhutdinov, Nariman F., Zenkova, Marina A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279002/ https://www.ncbi.nlm.nih.gov/pubmed/32429154 http://dx.doi.org/10.3390/ijms21103511

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