Understanding the Binding Induced Folding of Intrinsically Disordered Proteins by Protein Engineering: Caveats and Pitfalls

Many proteins lack a well-defined three-dimensional structure in isolation. These proteins, typically denoted as intrinsically disordered proteins (IDPs), may display a characteristic disorder-to-order transition when binding their physiological partner(s). From an experimental perspective, it is of...

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Detalles Bibliográficos
Autores principales: Malagrinò, Francesca, Visconti, Lorenzo, Pagano, Livia, Toto, Angelo, Troilo, Francesca, Gianni, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279032/
https://www.ncbi.nlm.nih.gov/pubmed/32429036
http://dx.doi.org/10.3390/ijms21103484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279032/
https://www.ncbi.nlm.nih.gov/pubmed/32429036
http://dx.doi.org/10.3390/ijms21103484

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