Cilastatin Preconditioning Attenuates Renal Ischemia-Reperfusion Injury via Hypoxia Inducible Factor-1α Activation

Cilastatin is a specific inhibitor of renal dehydrodipeptidase-1. We investigated whether cilastatin preconditioning attenuates renal ischemia-reperfusion (IR) injury via hypoxia inducible factor-1α (HIF-1α) activation. Human proximal tubular cell line (HK-2) was exposed to ischemia, and male C57BL/...

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Detalles Bibliográficos
Autores principales: Hong, Yu Ah, Jung, So Young, Yang, Keum Jin, Im, Dai Sig, Jeong, Kyung Hwan, Park, Cheol Whee, Hwang, Hyeon Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279043/
https://www.ncbi.nlm.nih.gov/pubmed/32438631
http://dx.doi.org/10.3390/ijms21103583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279043/
https://www.ncbi.nlm.nih.gov/pubmed/32438631
http://dx.doi.org/10.3390/ijms21103583

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