Clustering of the ζ-Chain Can Initiate T Cell Receptor Signaling

T cell activation is initiated when ligand binding to the T cell receptor (TCR) triggers intracellular phosphorylation of the TCR-CD3 complex. However, it remains unknown how biophysical properties of TCR engagement result in biochemical phosphorylation events. Here, we constructed an optogenetic to...

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Detalles Bibliográficos
Autores principales: Ma, Yuanqing, Lim, Yean J., Benda, Aleš, Lou, Jieqiong, Goyette, Jesse, Gaus, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279048/
https://www.ncbi.nlm.nih.gov/pubmed/32429097
http://dx.doi.org/10.3390/ijms21103498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279048/
https://www.ncbi.nlm.nih.gov/pubmed/32429097
http://dx.doi.org/10.3390/ijms21103498

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