DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses

DNA damage, caused by various oncogenic stresses, can induce cell death or cellular senescence as an important tumor suppressor mechanism. Senescent cells display the features of a senescence-associated secretory phenotype (SASP), secreting inflammatory proteins into surrounding tissues, and contrib...

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Detalles Bibliográficos
Autores principales: Hitomi, Kazuhiro, Okada, Ryo, Loo, Tze Mun, Miyata, Kenichi, Nakamura, Asako J., Takahashi, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279173/
https://www.ncbi.nlm.nih.gov/pubmed/32466233
http://dx.doi.org/10.3390/ijms21103720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279173/
https://www.ncbi.nlm.nih.gov/pubmed/32466233
http://dx.doi.org/10.3390/ijms21103720

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