Cargando…

Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis

RATIONALE: Mutations in the cystic fibrosis transmembrane regulator (CFTR) gene form the basis of cystic fibrosis (CF). There remains an important knowledge gap in CF as to how diminished CFTR activity leads to the dominant inflammatory response within CF airways. OBJECTIVES: To investigate if extra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Useckaite, Zivile, Ward, Mark P, Trappe, Anne, Reilly, Rebecca, Lennon, Jenny, Davage, Holly, Matallanas, David, Cassidy, Hilary, Dillon, Eugene T, Brennan, Kiva, Doyle, Sarah L, Carter, Suzanne, Donnelly, Seamas, Linnane, Barry, McKone, Edward F, McNally, Paul, Coppinger, Judith A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Cystic Fibrosis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279202/ https://www.ncbi.nlm.nih.gov/pubmed/32265339 http://dx.doi.org/10.1136/thoraxjnl-2019-214027

Ejemplares similares

Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis
por: Gray, Robert D, et al.
Publicado: (2018)

Validation and use of a parametric model for projecting cystic fibrosis survivorship beyond observed data: a birth cohort analysis
por: Jackson, Abaigeal D, et al.
Publicado: (2011)

Utility and validity of dynamic chest radiography in cystic fibrosis (dynamic CF): an observational, non-controlled, non-randomised, single-centre, prospective study
por: FitzMaurice, Thomas Simon, et al.
Publicado: (2020)

Feasibility of dynamic chest radiography to calculate lung volumes in adult people with cystic fibrosis: a pilot study
por: FitzMaurice, Thomas Simon, et al.
Publicado: (2023)

ROCK STUDY in CF: sustained anti-inflammatory effects of lumacaftor–ivacaftor in sputum and peripheral blood samples of adult patients with cystic fibrosis—an observational study
por: Arooj, Parniya, et al.
Publicado: (2023)

Is chest CT useful in newborn screened infants with cystic fibrosis at 1 year of age?
por: Thia, Lena P, et al.
Publicado: (2014)

Novel method to select meaningful outcomes for evaluation in clinical trials
por: McLeod, Charlie, et al.
Publicado: (2021)

Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung
por: Tagalakis, Aristides D, et al.
Publicado: (2018)

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis
por: Alton, Eric W F W, et al.
Publicado: (2017)

Short-term comparative study of high frequency chest wall oscillation and European airway clearance techniques in patients with cystic fibrosis
por: Osman, Leyla P, et al.
Publicado: (2009)

Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis
por: Wainwright, C E, et al.
Publicado: (2009)

Safety, efficacy and convenience of colistimethate sodium dry powder for inhalation (Colobreathe DPI) in patients with cystic fibrosis: a randomised study
por: Schuster, Antje, et al.
Publicado: (2013)

Viability of Pseudomonas aeruginosa in cough aerosols generated by persons with cystic fibrosis
por: Knibbs, Luke D, et al.
Publicado: (2014)

Evolution of lung function during the first year of life in newborn screened cystic fibrosis infants
por: Nguyen, The Thanh-Diem, et al.
Publicado: (2014)

Shortened Lung Clearance Index is a repeatable and sensitive test in children and adults with cystic fibrosis
por: Hannon, David, et al.
Publicado: (2014)

Eradication of Pseudomonas aeruginosa in adults with cystic fibrosis
por: Kenny, S L, et al.
Publicado: (2014)

Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection
por: Clancy, J P, et al.
Publicado: (2013)

Prospective evaluation of respiratory exacerbations in children with cystic fibrosis from newborn screening to 5 years of age
por: Byrnes, Catherine Ann, et al.
Publicado: (2013)

International Committee on Mental Health in Cystic Fibrosis: Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus statements for screening and treating depression and anxiety
por: Quittner, Alexandra L, et al.
Publicado: (2016)

Ciprofloxacin DPI: a randomised, placebo-controlled, phase IIb efficacy and safety study on cystic fibrosis
por: Dorkin, Henry L, et al.
Publicado: (2015)

Associations between genetics, medical status, physical exercise and psychological well-being in adults with cystic fibrosis
por: Backström-Eriksson, Lena, et al.
Publicado: (2016)

Timing of hypertonic saline and airway clearance techniques in adults with cystic fibrosis during pulmonary exacerbation: pilot data from a randomised crossover study
por: O'Neill, Katherine, et al.
Publicado: (2017)

Porphyromonas, a potential predictive biomarker of Pseudomonas aeruginosa pulmonary infection in cystic fibrosis
por: Keravec, Marlène, et al.
Publicado: (2019)

Impact of cystic fibrosis on birthweight: a population based study of children in Denmark and Wales
por: Schlüter, Daniela K, et al.
Publicado: (2019)

CNS imaging studies in cystic fibrosis patients presenting with sudden neurological events
por: Ellis, Samantha, et al.
Publicado: (2019)

Data from the US and UK cystic fibrosis registries support disease modification by CFTR modulation with ivacaftor
por: Bessonova, Leona, et al.
Publicado: (2018)

Randomised cross-over trial evaluating the short-term effects of non-invasive ventilation as an adjunct to airway clearance techniques in adults with cystic fibrosis
por: Stanford, Gemma, et al.
Publicado: (2019)

Intestinal current measurement and nasal potential difference to make a diagnosis of cases with inconclusive CFTR genetics and sweat test
por: Minso, Rebecca, et al.
Publicado: (2020)

Investigating outcome measures for assessing airway clearance techniques in adults with cystic fibrosis: protocol of a single-centre randomised controlled crossover trial
por: Stanford, Gemma, et al.
Publicado: (2020)

What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment?
por: Calthorpe, Rebecca J, et al.
Publicado: (2020)

How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey
por: Smith, Sherie, et al.
Publicado: (2020)

Impact of newborn screening on outcomes and social inequalities in cystic fibrosis: a UK CF registry-based study
por: Schlüter, Daniela K, et al.
Publicado: (2020)

Downregulation of epithelial sodium channel (ENaC) activity in human airway epithelia after low temperature incubation
por: Yadav, Sangya, et al.
Publicado: (2021)

Lung function in children with cystic fibrosis in the USA and UK: a comparative longitudinal analysis of national registry data
por: Schlüter, Daniela K, et al.
Publicado: (2022)

Coil embolisation for massive haemoptysis in cystic fibrosis
por: Dohna, Martha, et al.
Publicado: (2021)

Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trial
por: Nichols, David P, et al.
Publicado: (2022)

Self-management intervention to reduce pulmonary exacerbations by supporting treatment adherence in adults with cystic fibrosis: a randomised controlled trial
por: Wildman, Martin J, et al.
Publicado: (2022)

Adherence to cystic fibrosis transmembrane conductance regulator (CFTR) modulators: analysis of a national specialty pharmacy database
por: Mehta, Zumi, et al.
Publicado: (2021)

Survival models to support shared decision-making about advance care planning for people with advanced stage cystic fibrosis
por: Hajizadeh, Negin, et al.
Publicado: (2021)

Variation in treatment preferences of pulmonary exacerbations among Australian and New Zealand cystic fibrosis physicians
por: Currie, Grace, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vv7ijrjr130gg60iibv4nf6111