On-Target CRISPR/Cas9 Activity Can Cause Undesigned Large Deletion in Mouse Zygotes

Genome engineering has been tremendously affected by the appearance of the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9)-based approach. Initially discovered as an adaptive immune system for prokaryotes, the method has rapidly evolved ov...

Descripción completa

Detalles Bibliográficos
Autores principales: Korablev, Alexey, Lukyanchikova, Varvara, Serova, Irina, Battulin, Nariman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279260/
https://www.ncbi.nlm.nih.gov/pubmed/32443745
http://dx.doi.org/10.3390/ijms21103604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279260/
https://www.ncbi.nlm.nih.gov/pubmed/32443745
http://dx.doi.org/10.3390/ijms21103604

Ejemplares similares