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Increased blood-brain barrier hyperpermeability coincides with mast cell activation early under cuprizone administration

The cuprizone induced animal model of demyelination is characterized by demyelination in many regions of the brain with high levels of demyelination in the corpus callosum as well as changes in neuronal function by 4–6 weeks of exposure. The model is used as a tool to study demyelination and subsequ...

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Detalles Bibliográficos
Autores principales: Shelestak, John, Singhal, Naveen, Frankle, Lana, Tomor, Riely, Sternbach, Sarah, McDonough, Jennifer, Freeman, Ernest, Clements, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279587/
https://www.ncbi.nlm.nih.gov/pubmed/32511268
http://dx.doi.org/10.1371/journal.pone.0234001