COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of Nontypeable Haemophilus influenzae and May Be Potentiated by Macrolide Arrest of Autophagy

INTRODUCTION: COPD is an inflammatory airway pathology associated with recurrent infection by nontypeable Haemophilus influenzae (NTHi) that is not effectively managed by macrolide antibiotic therapy. We hypothesised that NTHi is able to reside intracellularly within COPD-derived airway epithelial c...

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Detalles Bibliográficos
Autores principales: Poh, Wee-Peng, Kicic, Anthony, Lester, Susan E, Nguyen, Phan T, Bakaletz, Lauren O, Reynolds, Paul N, Hodge, Sandra, Roscioli, Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279738/
https://www.ncbi.nlm.nih.gov/pubmed/32581530
http://dx.doi.org/10.2147/COPD.S245819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279738/
https://www.ncbi.nlm.nih.gov/pubmed/32581530
http://dx.doi.org/10.2147/COPD.S245819

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