A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

EDC4 is a core component of processing (P)-bodies that binds the DCP2 decapping enzyme and stimulates mRNA decay. EDC4 also interacts with mammalian MARF1, a recently identified endoribonuclease that promotes oogenesis and contains a number of RNA binding domains, including two RRMs and multiple LOT...

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Detalles Bibliográficos
Autores principales: Brothers, William R, Hebert, Steven, Kleinman, Claudia L, Fabian, Marc R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279887/
https://www.ncbi.nlm.nih.gov/pubmed/32510323
http://dx.doi.org/10.7554/eLife.54995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279887/
https://www.ncbi.nlm.nih.gov/pubmed/32510323
http://dx.doi.org/10.7554/eLife.54995

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