Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation

Vitamin A is stored as retinyl esters (REs) in lipid droplets of hepatic stellate cells (HSCs). To date, two different pathways are known to facilitate the breakdown of REs: (i) Hydrolysis of REs by neutral lipases, and (ii) whole lipid droplet degradation in autolysosomes by acid hydrolysis. In thi...

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Detalles Bibliográficos
Autores principales: Wagner, Carina, Hois, Victoria, Pajed, Laura, Pusch, Lisa-Maria, Wolinski, Heimo, Trauner, Michael, Zimmermann, Robert, Taschler, Ulrike, Lass, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279957/
https://www.ncbi.nlm.nih.gov/pubmed/32361002
http://dx.doi.org/10.1016/j.bbalip.2020.158730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279957/
https://www.ncbi.nlm.nih.gov/pubmed/32361002
http://dx.doi.org/10.1016/j.bbalip.2020.158730

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