A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU)
To decrypt the complexity of the posttraumatic immune responses and to potentially identify novel research pathways for exploration, large-scale multi-center projects including not only in vivo and in vitro modeling, but also temporal sample and material collection along with clinical data capture f...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280175/ https://www.ncbi.nlm.nih.gov/pubmed/31324937 http://dx.doi.org/10.1007/s00068-019-01193-3 |
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author | Relja, Borna Huber-Lang, Markus van Griensven, Martijn Hildebrand, Frank Maegele, Marc Nienaber, Ulrike Brucker, Daniel P. Sturm, Ramona Marzi, Ingo |
author_facet | Relja, Borna Huber-Lang, Markus van Griensven, Martijn Hildebrand, Frank Maegele, Marc Nienaber, Ulrike Brucker, Daniel P. Sturm, Ramona Marzi, Ingo |
author_sort | Relja, Borna |
collection | PubMed |
description | To decrypt the complexity of the posttraumatic immune responses and to potentially identify novel research pathways for exploration, large-scale multi-center projects including not only in vivo and in vitro modeling, but also temporal sample and material collection along with clinical data capture from multiply injured patients is of utmost importance. To meet this gap, a nationwide biobank for fluidic samples from polytraumatized patients was initiated in 2013 by the task force Network “Trauma Research” (Netzwerk Traumaforschung, NTF) of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie e.V., DGU). The NTF-Biobank completes the clinical NTF-Biobank Database and complements the TR-DGU with temporal biological samples from multiply injured patients. The concept behind the idea of the NTF-Biobank was to create a robust interface for meaningful innovative basic, translational and clinical research. For the first time, an integrated platform to prospectively evaluate and monitor candidate biomarkers and/or potential therapeutic targets in biological specimens of quality-controlled and documented patients is introduced, allowing reduction in variability of measurements with high impact due to its large sample size. Thus, the project was introduced to systemically evaluate and monitor multiply injured patients for their (patho-)physiological sequalae together with their clinical treatment strategies applied for overall outcome improval. |
format | Online Article Text |
id | pubmed-7280175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-72801752020-06-15 A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU) Relja, Borna Huber-Lang, Markus van Griensven, Martijn Hildebrand, Frank Maegele, Marc Nienaber, Ulrike Brucker, Daniel P. Sturm, Ramona Marzi, Ingo Eur J Trauma Emerg Surg Review Article To decrypt the complexity of the posttraumatic immune responses and to potentially identify novel research pathways for exploration, large-scale multi-center projects including not only in vivo and in vitro modeling, but also temporal sample and material collection along with clinical data capture from multiply injured patients is of utmost importance. To meet this gap, a nationwide biobank for fluidic samples from polytraumatized patients was initiated in 2013 by the task force Network “Trauma Research” (Netzwerk Traumaforschung, NTF) of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie e.V., DGU). The NTF-Biobank completes the clinical NTF-Biobank Database and complements the TR-DGU with temporal biological samples from multiply injured patients. The concept behind the idea of the NTF-Biobank was to create a robust interface for meaningful innovative basic, translational and clinical research. For the first time, an integrated platform to prospectively evaluate and monitor candidate biomarkers and/or potential therapeutic targets in biological specimens of quality-controlled and documented patients is introduced, allowing reduction in variability of measurements with high impact due to its large sample size. Thus, the project was introduced to systemically evaluate and monitor multiply injured patients for their (patho-)physiological sequalae together with their clinical treatment strategies applied for overall outcome improval. Springer Berlin Heidelberg 2019-07-19 2020 /pmc/articles/PMC7280175/ /pubmed/31324937 http://dx.doi.org/10.1007/s00068-019-01193-3 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Article Relja, Borna Huber-Lang, Markus van Griensven, Martijn Hildebrand, Frank Maegele, Marc Nienaber, Ulrike Brucker, Daniel P. Sturm, Ramona Marzi, Ingo A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU) |
title | A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU) |
title_full | A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU) |
title_fullStr | A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU) |
title_full_unstemmed | A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU) |
title_short | A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU) |
title_sort | nationwide fluidics biobank of polytraumatized patients: implemented by the network “trauma research” (ntf) as an expansion to the traumaregister dgu(®) of the german trauma society (dgu) |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280175/ https://www.ncbi.nlm.nih.gov/pubmed/31324937 http://dx.doi.org/10.1007/s00068-019-01193-3 |
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