A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU)

To decrypt the complexity of the posttraumatic immune responses and to potentially identify novel research pathways for exploration, large-scale multi-center projects including not only in vivo and in vitro modeling, but also temporal sample and material collection along with clinical data capture f...

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Autores principales: Relja, Borna, Huber-Lang, Markus, van Griensven, Martijn, Hildebrand, Frank, Maegele, Marc, Nienaber, Ulrike, Brucker, Daniel P., Sturm, Ramona, Marzi, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280175/
https://www.ncbi.nlm.nih.gov/pubmed/31324937
http://dx.doi.org/10.1007/s00068-019-01193-3
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author Relja, Borna
Huber-Lang, Markus
van Griensven, Martijn
Hildebrand, Frank
Maegele, Marc
Nienaber, Ulrike
Brucker, Daniel P.
Sturm, Ramona
Marzi, Ingo
author_facet Relja, Borna
Huber-Lang, Markus
van Griensven, Martijn
Hildebrand, Frank
Maegele, Marc
Nienaber, Ulrike
Brucker, Daniel P.
Sturm, Ramona
Marzi, Ingo
author_sort Relja, Borna
collection PubMed
description To decrypt the complexity of the posttraumatic immune responses and to potentially identify novel research pathways for exploration, large-scale multi-center projects including not only in vivo and in vitro modeling, but also temporal sample and material collection along with clinical data capture from multiply injured patients is of utmost importance. To meet this gap, a nationwide biobank for fluidic samples from polytraumatized patients was initiated in 2013 by the task force Network “Trauma Research” (Netzwerk Traumaforschung, NTF) of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie e.V., DGU). The NTF-Biobank completes the clinical NTF-Biobank Database and complements the TR-DGU with temporal biological samples from multiply injured patients. The concept behind the idea of the NTF-Biobank was to create a robust interface for meaningful innovative basic, translational and clinical research. For the first time, an integrated platform to prospectively evaluate and monitor candidate biomarkers and/or potential therapeutic targets in biological specimens of quality-controlled and documented patients is introduced, allowing reduction in variability of measurements with high impact due to its large sample size. Thus, the project was introduced to systemically evaluate and monitor multiply injured patients for their (patho-)physiological sequalae together with their clinical treatment strategies applied for overall outcome improval.
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spelling pubmed-72801752020-06-15 A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU) Relja, Borna Huber-Lang, Markus van Griensven, Martijn Hildebrand, Frank Maegele, Marc Nienaber, Ulrike Brucker, Daniel P. Sturm, Ramona Marzi, Ingo Eur J Trauma Emerg Surg Review Article To decrypt the complexity of the posttraumatic immune responses and to potentially identify novel research pathways for exploration, large-scale multi-center projects including not only in vivo and in vitro modeling, but also temporal sample and material collection along with clinical data capture from multiply injured patients is of utmost importance. To meet this gap, a nationwide biobank for fluidic samples from polytraumatized patients was initiated in 2013 by the task force Network “Trauma Research” (Netzwerk Traumaforschung, NTF) of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie e.V., DGU). The NTF-Biobank completes the clinical NTF-Biobank Database and complements the TR-DGU with temporal biological samples from multiply injured patients. The concept behind the idea of the NTF-Biobank was to create a robust interface for meaningful innovative basic, translational and clinical research. For the first time, an integrated platform to prospectively evaluate and monitor candidate biomarkers and/or potential therapeutic targets in biological specimens of quality-controlled and documented patients is introduced, allowing reduction in variability of measurements with high impact due to its large sample size. Thus, the project was introduced to systemically evaluate and monitor multiply injured patients for their (patho-)physiological sequalae together with their clinical treatment strategies applied for overall outcome improval. Springer Berlin Heidelberg 2019-07-19 2020 /pmc/articles/PMC7280175/ /pubmed/31324937 http://dx.doi.org/10.1007/s00068-019-01193-3 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Relja, Borna
Huber-Lang, Markus
van Griensven, Martijn
Hildebrand, Frank
Maegele, Marc
Nienaber, Ulrike
Brucker, Daniel P.
Sturm, Ramona
Marzi, Ingo
A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU)
title A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU)
title_full A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU)
title_fullStr A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU)
title_full_unstemmed A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU)
title_short A nationwide fluidics biobank of polytraumatized patients: implemented by the Network “Trauma Research” (NTF) as an expansion to the TraumaRegister DGU(®) of the German Trauma Society (DGU)
title_sort nationwide fluidics biobank of polytraumatized patients: implemented by the network “trauma research” (ntf) as an expansion to the traumaregister dgu(®) of the german trauma society (dgu)
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280175/
https://www.ncbi.nlm.nih.gov/pubmed/31324937
http://dx.doi.org/10.1007/s00068-019-01193-3
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