Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression

Sigma-1 and sigma-2 receptors are emerging therapeutic targets. We have identified that simple ammonium salts bind to these receptors and are effective in vivo. Radioligand binding assays were used to obtain structure-activity relationships of these salts. MTS assays were performed to determine thei...

Descripción completa

Detalles Bibliográficos
Autores principales: Brimson, James M., Akula, Kiran K., Abbas, Haider, Ferry, David R., Kulkarni, Shrinivas K., Russell, Steven T., Tisdale, Michael J., Tencomnao, Tewin, Safrany, Stephen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280195/
https://www.ncbi.nlm.nih.gov/pubmed/32514120
http://dx.doi.org/10.1038/s41598-020-65849-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280195/
https://www.ncbi.nlm.nih.gov/pubmed/32514120
http://dx.doi.org/10.1038/s41598-020-65849-6

Ejemplares similares