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Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression
Sigma-1 and sigma-2 receptors are emerging therapeutic targets. We have identified that simple ammonium salts bind to these receptors and are effective in vivo. Radioligand binding assays were used to obtain structure-activity relationships of these salts. MTS assays were performed to determine thei...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280195/ https://www.ncbi.nlm.nih.gov/pubmed/32514120 http://dx.doi.org/10.1038/s41598-020-65849-6 |