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Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1
Cells from two murine lymphoid lines died 24–48 h after treatment with the glucocorticoid dexamethasone. Deletion of Bax and Bak1 prevented rapid apoptosis, but treatment with dexamethasone for greater 6 days still led to cell death that was characterized by release of cytochrome c into the cytosol,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280233/ https://www.ncbi.nlm.nih.gov/pubmed/32513923 http://dx.doi.org/10.1038/s41419-020-2599-5 |