Cilostazol restores autophagy flux in bafilomycin A1-treated, cultured cortical astrocytes through lysosomal reacidification: roles of PKA, zinc and metallothionein 3

Cilostazol, a phosphodiesterase 3 inhibitor, reduces the amyloid-beta (Aβ) burden in mouse models of Alzheimer disease by as yet unidentified mechanisms. In the present study, we examined the possibility that cilostazol ameliorates lysosomal dysfunction. Astrocytes treated with bafilomycin A1 (BafA1...

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Detalles Bibliográficos
Autores principales: Kim, Ha Na, Seo, Bo-Ra, Kim, Hyunjin, Koh, Jae-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280249/
https://www.ncbi.nlm.nih.gov/pubmed/32514052
http://dx.doi.org/10.1038/s41598-020-66292-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280249/
https://www.ncbi.nlm.nih.gov/pubmed/32514052
http://dx.doi.org/10.1038/s41598-020-66292-3

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