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PAWI-2 overcomes tumor stemness and drug resistance via cell cycle arrest in integrin β(3)-KRAS-dependent pancreatic cancer stem cells
Today, pancreatic cancer (PC) remains a major health problem in the US. The fact that cancer stem cells (CSCs) become enriched in humans following anti-cancer therapy implicates CSCs as key contributors to tumor dormancy, metastasis, and relapse in PC. A highly validated CSC model (FGβ(3) cells) was...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280251/ https://www.ncbi.nlm.nih.gov/pubmed/32514015 http://dx.doi.org/10.1038/s41598-020-65804-5 |