Novel XIAP mutation causing enhanced spontaneous apoptosis and disturbed NOD2 signalling in a patient with atypical adult-onset Crohn’s disease

X-linked inhibitor of apoptosis (XIAP) is the most potent human inhibitor of apoptosis, and is also involved in NOD2-dependent NFκB and MAPK signalling cascade activation. The absence or defective function of XIAP leads to the development of a rare and severe primary immunodeficiency known as X-link...

Descripción completa

Detalles Bibliográficos
Autores principales: Parackova, Zuzana, Milota, Tomas, Vrabcova, Petra, Smetanova, Jitka, Svaton, Michael, Freiberger, Tomas, Kanderova, Veronika, Sediva, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280281/
https://www.ncbi.nlm.nih.gov/pubmed/32514016
http://dx.doi.org/10.1038/s41419-020-2652-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280281/
https://www.ncbi.nlm.nih.gov/pubmed/32514016
http://dx.doi.org/10.1038/s41419-020-2652-4

Ejemplares similares