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A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer
Aberrant activation of Wnt/β-catenin signaling has been associated with the onset and progression of many types of tumors and thus β-catenin represents one attractive intracellular target for cancer therapy. Based on the Axin-derived peptide that binds to β-catenin, two stapled peptides SAHPA1 and x...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280531/ https://www.ncbi.nlm.nih.gov/pubmed/32550000 http://dx.doi.org/10.1038/s41421-020-0171-1 |