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A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer

Aberrant activation of Wnt/β-catenin signaling has been associated with the onset and progression of many types of tumors and thus β-catenin represents one attractive intracellular target for cancer therapy. Based on the Axin-derived peptide that binds to β-catenin, two stapled peptides SAHPA1 and x...

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Detalles Bibliográficos
Autores principales:	Liao, Hongwei, Li, Xiang, Zhao, Lianzheng, Wang, Yalong, Wang, Xiaodan, Wu, Ye, Zhou, Xin, Fu, Wei, Liu, Lei, Hu, Hong-Gang, Chen, Ye-Guang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280531/ https://www.ncbi.nlm.nih.gov/pubmed/32550000 http://dx.doi.org/10.1038/s41421-020-0171-1

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