Cargando…

Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity

Here, we developed a novel oncolytic vaccinia virus (NOV) with the dual advantages of cancer selectivity and normal vessel reconstructive activity by replacing the viral thymidine kinase (vTk) and vaccinia growth factor (VGF) genes with genes encoding TNF-related apoptosis-inducing ligand (TRAIL) an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeong, Su-Nam, Yoo, So Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281019/ https://www.ncbi.nlm.nih.gov/pubmed/32344903 http://dx.doi.org/10.3390/cancers12051070

Ejemplares similares

Armed oncolytic viruses: A kick-start for anti-tumor immunity
por: de Graaf, J.F., et al.
Publicado: (2018)

Beyond cancer cells: Targeting the tumor microenvironment with gene therapy and armed oncolytic virus
por: Wan, Peter Kok-Ting, et al.
Publicado: (2021)

Oncolytic Virus-Based Immunotherapies for Hepatocellular Carcinoma
por: Yoo, So Young, et al.
Publicado: (2017)

A cancer-favoring oncolytic vaccinia virus shows enhanced suppression of stem-cell like colon cancer
por: Yoo, So Young, et al.
Publicado: (2016)

IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy
por: Chen, Tianyue, et al.
Publicado: (2021)

Oncolytic Vaccinia Virus in Lung Cancer Vaccines
por: Truong, Cao-Sang, et al.
Publicado: (2022)

The Enhanced Tumor Specificity of TG6002, an Armed Oncolytic Vaccinia Virus Deleted in Two Genes Involved in Nucleotide Metabolism
por: Foloppe, Johann, et al.
Publicado: (2019)

Suicide gene-armed measles vaccine virus for the treatment of AML
por: Maurer, Stefanie, et al.
Publicado: (2019)

Correction: IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy
Publicado: (2021)

Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy Perspective
por: Muthukutty, Palaniyandi, et al.
Publicado: (2023)

Cowpox Virus: A New and Armed Oncolytic Poxvirus
por: Ricordel, Marine, et al.
Publicado: (2017)

Overcoming Tumor Resistance to Oncolyticvaccinia Virus with Anti-PD-1-Based Combination Therapy by Inducing Antitumor Immunity in the Tumor Microenvironment
por: Yoo, So Young, et al.
Publicado: (2020)

Oncolytic virotherapy targeting the IL15 pathway
por: Yoo, So Young, et al.
Publicado: (2023)

An Oncolytic Vaccinia Virus Armed with GM-CSF and IL-24 Double Genes for Cancer Targeted Therapy
por: Deng, Lili, et al.
Publicado: (2020)

Harnessing Oncolytic Virus-Mediated Anti-Tumor Immunity
por: Schirrmacher, Volker, et al.
Publicado: (2014)

Anti-Tumor Effects of MAPK-Dependent Tumor-Selective Oncolytic Vaccinia Virus Armed with CD/UPRT against Pancreatic Ductal Adenocarcinoma in Mice
por: Kurosaki, Hajime, et al.
Publicado: (2021)

Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes
por: Labani-Motlagh, Alireza, et al.
Publicado: (2021)

Pharmacological Modulation of Anti-Tumor Immunity Induced by Oncolytic Viruses
por: Forbes, Nicole E., et al.
Publicado: (2014)

Combination of IAP Antagonists and TNF-α-Armed Oncolytic Viruses Induce Tumor Vascular Shutdown and Tumor Regression
por: Beug, Shawn T., et al.
Publicado: (2018)

Dual-Armed Oncolytic Myxoma Virus Encoding IFN-γ and CD47 Promotes Lymphocyte Infiltration and Tumor Suppression of Syngeneic Murine Melanoma
por: Woo, Jong Kyu, et al.
Publicado: (2023)

Targeting lung cancer stem-like cells with TRAIL gene armed oncolytic adenovirus
por: Yang, Yu, et al.
Publicado: (2015)

Tumor Restrictions to Oncolytic Virus
por: Vähä-Koskela, Markus, et al.
Publicado: (2014)

Oncolytic virotherapy with an armed vaccinia virus in an orthotopic model of renal carcinoma is associated with modification of the tumor microenvironment
por: Fend, Laetitia, et al.
Publicado: (2015)

The combination therapy of oncolytic HSV-1 armed with anti-PD-1 antibody and IL-12 enhances anti-tumor efficacy
por: Xie, Xin, et al.
Publicado: (2021)

Evidence of Anti-tumoral Efficacy in an Immune Competent Setting with an iRGD-Modified Hyaluronidase-Armed Oncolytic Adenovirus
por: Al-Zaher, Ahmed Abdullah, et al.
Publicado: (2018)

Immunostimulatory Gene Therapy Using Oncolytic Viruses as Vehicles
por: Loskog, Angelica
Publicado: (2015)

Monitoring the Efficacy of Oncolytic Viruses via Gene Expression
por: Ansel, Ashley, et al.
Publicado: (2017)

TRAIL Gene-Armed Oncolytic Poxvirus and Oxaliplatin Can Work Synergistically against Colorectal Cancer
por: Ziauddin, Mohammed F, et al.
Publicado: (2010)

HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses
por: Menotti, Laura, et al.
Publicado: (2018)

Graphene oxide arms oncolytic measles virus for improved effectiveness of cancer therapy
por: Xia, Mao, et al.
Publicado: (2019)

Arming HSV-Based Oncolytic Viruses with the Ability to Redirect the Host’s Innate Antiviral Immunity to Attack Tumor Cells
por: Fu, Xinping, et al.
Publicado: (2020)

Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus
por: Havunen, Riikka, et al.
Publicado: (2018)

Oncolytic virus-based suicide gene therapy for cancer treatment: a perspective of the clinical trials conducted at Henry Ford Health
por: Thoidingjam, Shivani, et al.
Publicado: (2023)

Vasculogenic mimicry
por: Pandiar, Deepak, et al.
Publicado: (2023)

CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy
por: Li, Xiaofei, et al.
Publicado: (2022)

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments
por: Wei, Xiaoxu, et al.
Publicado: (2021)

Therapeutic potential of vasculogenic mimicry in urological tumors
por: Lin, Xinyu, et al.
Publicado: (2023)

Stability and anti-tumor effect of oncolytic herpes simplex virus type 2
por: Wang, Yang, et al.
Publicado: (2018)

GENT: Gene Expression Database of Normal and Tumor Tissues
por: Shin, Gwangsik, et al.
Publicado: (2011)

Gene expression profiling of hematologic malignant cell lines resistant to oncolytic virus treatment
por: Lee, Nam Hee, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_k9345ged3p1ibrsc6kn0so0gms