Cargando…

WRN-Mutated Colorectal Cancer Is Characterized by a Distinct Genetic Phenotype

Werner syndrome gene (WRN) contributes to DNA repair. In cancer, WRN mutations (WRN-mut) lead to genomic instability. Thus, WRN is a promising target in cancers with microsatellite instability (MSI). We assessed this study to investigate the molecular profile of WRN-mut in colorectal cancer (CRC). T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zimmer, Kai, Puccini, Alberto, Xiu, Joanne, Baca, Yasmine, Spizzo, Gilbert, Lenz, Heinz-Josef, Battaglin, Francesca, Goldberg, Richard M., Grothey, Axel, Shields, Anthony F., Salem, Mohamed E., Marshall, John L., Korn, W. Michael, Wolf, Dominik, Kocher, Florian, Seeber, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281075/ https://www.ncbi.nlm.nih.gov/pubmed/32455893 http://dx.doi.org/10.3390/cancers12051319

Ejemplares similares

Molecular characteristics of BRCA1/2 and PALB2 mutations in pancreatic ductal adenocarcinoma
por: Seeber, Andreas, et al.
Publicado: (2020)

Molecular profile of BRCA-mutated biliary tract cancers
por: Spizzo, Gilbert, et al.
Publicado: (2020)

Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer
por: Seeber, Andreas, et al.
Publicado: (2022)

Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets
por: Kocher, Florian, et al.
Publicado: (2022)

Molecular differences between lymph nodes and distant metastases compared with primaries in colorectal cancer patients
por: Puccini, Alberto, et al.
Publicado: (2021)

Treatment According to Molecular Profiling in Relapsed/Refractory Cancer Patients: A Review Focusing on Latest Profiling Studies
por: Zimmer, Kai, et al.
Publicado: (2019)

Overcoming resistance to anti-PD1 and anti-PD-L1 treatment in gastrointestinal malignancies
por: Puccini, Alberto, et al.
Publicado: (2020)

Molecular biomarkers in gastro-esophageal cancer: recent developments, current trends and future directions
por: Battaglin, Francesca, et al.
Publicado: (2018)

The impact of panitumumab treatment on survival and quality of life in patients with RAS wild-type metastatic colorectal cancer
por: Battaglin, Francesca, et al.
Publicado: (2019)

Targeting BRCA and DNA Damage Repair Genes in GI Cancers: Pathophysiology and Clinical Perspectives
por: Zimmer, Kai, et al.
Publicado: (2021)

PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system
por: Zimmer, Kai, et al.
Publicado: (2023)

Expression of Immuno-Oncologic Biomarkers Is Enriched in Colorectal Cancers and Other Solid Tumors Harboring the A59T Variant of KRAS
por: Lou, Emil, et al.
Publicado: (2021)

The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA
por: Sharma, Sudha, et al.
Publicado: (2005)

Concise Review: Aggressive Colorectal Cancer: Role of Epithelial Cell Adhesion Molecule in Cancer Stem Cells and Epithelial‐to‐Mesenchymal Transition
por: Boesch, Maximilian, et al.
Publicado: (2018)

New perspectives for colorectal cancer
por: Puccini, Alberto, et al.
Publicado: (2017)

CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double‐strand break repair pathway choice
por: Lee, Jong‐Hyuk, et al.
Publicado: (2021)

Unraveling the roles of WRN and DNA-PKcs at telomeres
por: Beattie, Tara L., et al.
Publicado: (2010)

Pharmacogenomics in colorectal cancer: current role in clinical practice and future perspectives
por: Battaglin, Francesca, et al.
Publicado: (2018)

CDK1 phosphorylates WRN at collapsed replication forks
por: Palermo, Valentina, et al.
Publicado: (2016)

Curcumin: New Insights into an Ancient Ingredient against Cancer
por: Willenbacher, Ella, et al.
Publicado: (2019)

Erratum: Willenbacher, E., et al. Curcumin: New Insights into an Ancient Ingredient against Cancer. Int. J. Mol. Sci. 2019, 20, 1808
por: Willenbacher, Ella, et al.
Publicado: (2020)

Acetylation of WRN Protein Regulates Its Stability by Inhibiting Ubiquitination
por: Li, Kai, et al.
Publicado: (2010)

Structural mechanisms of human RecQ helicases WRN and BLM
por: Kitano, Ken
Publicado: (2014)

Multiple RPAs make WRN syndrome protein a superhelicase
por: Lee, Mina, et al.
Publicado: (2018)

Clinical prospects of WRN inhibition as a treatment for MSI tumours
por: Morales-Juarez, David A., et al.
Publicado: (2022)

Treatment of patients with refractory metastatic cancer according to molecular profiling on tumor tissue in the clinical routine: an interim-analysis of the ONCO-T-PROFILE project
por: Seeber, Andreas, et al.
Publicado: (2016)

Comparative molecular analyses of left-sided colon, right-sided colon, and rectal cancers
por: Salem, Mohamed E., et al.
Publicado: (2017)

Replication fork regression in vitro by the Werner syndrome protein (WRN): Holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity
por: Machwe, Amrita, et al.
Publicado: (2007)

Impact and Novel Perspective of Immune Checkpoint Inhibitors in Patients with Early and Intermediate Stage HCC
por: Marzi, Luca, et al.
Publicado: (2022)

c-Myc Accelerates S-Phase and Requires WRN to Avoid Replication Stress
por: Robinson, Kristin, et al.
Publicado: (2009)

Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops
por: Kusumoto-Matsuo, Rika, et al.
Publicado: (2010)

WRN Loss Induces Switching of Telomerase-Independent Mechanisms of Telomere Elongation
por: Gocha, April Renee Sandy, et al.
Publicado: (2014)

The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres
por: Mendez-Bermudez, Aaron, et al.
Publicado: (2012)

Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer
por: Shamanna, Raghavendra A., et al.
Publicado: (2016)

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers
por: Chan, Edmond M., et al.
Publicado: (2019)

R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1
por: Marabitti, Veronica, et al.
Publicado: (2022)

High indoleamine-2,3-dioxygenase 1 (IDO) activity is linked to primary resistance to immunotherapy in non-small cell lung cancer (NSCLC)
por: Kocher, Florian, et al.
Publicado: (2021)

Disseminated focal (18)F-fluoro-deoxyglucose uptake upon granulocyte colony-stimulating factor therapy mimicking malignant bone infiltration: case report of a patient with very severe aplastic anemia
por: Horvath, Lena, et al.
Publicado: (2020)

Case report: successful perioperative management of patients with haemophilia A using an extended half-life factor VIII (Efmoroctocog alfa) during neurosurgical procedures
por: Kocher, Florian, et al.
Publicado: (2021)

Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair
por: Muftuoglu, Meltem, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_dpp97rjje4fjl96ed726ff2d8f