YM155-Adapted Cancer Cell Lines Reveal Drug-Induced Heterogeneity and Enable the Identification of Biomarker Candidates for the Acquired Resistance Setting

Survivin is a drug target and its suppressant YM155 a drug candidate mainly investigated for high-risk neuroblastoma. Findings from one YM155-adapted subline of the neuroblastoma cell line UKF-NB-3 had suggested that increased ABCB1 (mediates YM155 efflux) levels, decreased SLC35F2 (mediates YM155 u...

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Detalles Bibliográficos
Autores principales: Michaelis, Martin, Wass, Mark N., Reddin, Ian, Voges, Yvonne, Rothweiler, Florian, Hehlgans, Stephanie, Cinatl, Jaroslav, Mernberger, Marco, Nist, Andrea, Stiewe, Thorsten, Rödel, Franz, Cinatl, Jindrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281096/
https://www.ncbi.nlm.nih.gov/pubmed/32357518
http://dx.doi.org/10.3390/cancers12051080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281096/
https://www.ncbi.nlm.nih.gov/pubmed/32357518
http://dx.doi.org/10.3390/cancers12051080

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