Cargando…

Immune Cytolytic Activity for Comprehensive Understanding of Immune Landscape in Hepatocellular Carcinoma

Cytolytic activity score (CYT), defined by granzyme A and perforin expression, is a useful marker for underlying immunity. We hypothesized that CYT-high hepatocellular carcinomas (HCCs) have stronger immunogenicity and favorable tumor microenvironments, which would result in better clinical outcomes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takahashi, Hideo, Kawaguchi, Tsutomu, Yan, Li, Peng, Xuan, Qi, Qianya, Morris, Luc G.T., Chan, Timothy A., Tsung, Allan, Otsuji, Eigo, Takabe, Kazuaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281225/ https://www.ncbi.nlm.nih.gov/pubmed/32414098 http://dx.doi.org/10.3390/cancers12051221

Ejemplares similares

Immune Cytolytic Activity for Comprehensive Insights of the Immune Landscape in Endometrial Carcinoma
por: Chen, Qiang, et al.
Publicado: (2022)

Estrogen Receptor Positive Breast Cancer with High Expression of Androgen Receptor has Less Cytolytic Activity and Worse Response to Neoadjuvant Chemotherapy but Better Survival
por: Okano, Maiko, et al.
Publicado: (2019)

Tumor Infiltrating Lymphocytes and Macrophages Improve Survival in Microsatellite Unstable Colorectal Cancer
por: Narayanan, Sumana, et al.
Publicado: (2019)

Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival
por: Young, Jessica, et al.
Publicado: (2017)

Overexpression of suppressive microRNAs, miR-30a and miR-200c are associated with improved survival of breast cancer patients
por: Kawaguchi, Tsutomu, et al.
Publicado: (2017)

Octogenarians’ Breast Cancer Is Associated with an Unfavorable Tumor Immune Microenvironment and Worse Disease-Free Survival
por: Okano, Maiko, et al.
Publicado: (2021)

Ceramide species are elevated in human breast cancer and are associated with less aggressiveness
por: Moro, Kazuki, et al.
Publicado: (2018)

Mirizzi syndrome with an unusual type of biliobiliary fistula—a case report
por: Kawaguchi, Tsutomu, et al.
Publicado: (2015)

Laparoscopic repair of a bilateral internal inguinal hernia with supravesical hernia – a case report
por: Kawaguchi, Tsutomu, et al.
Publicado: (2015)

Pancreatic adenocarcinomas with mature blood vessels have better overall survival
por: Katsuta, Eriko, et al.
Publicado: (2019)

Class I histone deacetylase inhibitor suppresses vasculogenic mimicry by enhancing the expression of tumor suppressor and anti-angiogenesis genes in aggressive human TNBC cells
por: Maiti, Aparna, et al.
Publicado: (2019)

Immune Cytolytic Activity as an Indicator of Immune Checkpoint Inhibitors Treatment for Prostate Cancer
por: Gao, Ze, et al.
Publicado: (2020)

Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
por: Ganly, Ian, et al.
Publicado: (2023)

Immune Cytolytic Activity Is Associated With Genetic and Clinical Properties of Glioma
por: Wang, Zhi-liang, et al.
Publicado: (2019)

The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis
por: Roufas, Constantinos, et al.
Publicado: (2018)

Biologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate
por: Takahashi, Hideo, et al.
Publicado: (2020)

A Case of Neuroendocrine Cell Carcinoma with Sigmoidovesical Fistula
por: Kawaguchi, Tsutomu, et al.
Publicado: (2010)

The role of immune surveillance in malignant transformation of benign salivary gland tumors
por: Linxweiler, Maximilian, et al.
Publicado: (2021)

Desirable cytolytic immune effector cell recruitment by interleukin-15 dendritic cells
por: Van Acker, Heleen H., et al.
Publicado: (2017)

Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration
por: Zhao, Boyang, et al.
Publicado: (2019)

Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis
por: Roufas, Constantinos, et al.
Publicado: (2021)

A Comprehensive Survey of Immune Cytolytic Activity-Associated Gene Co-Expression Networks across 17 Tumor and Normal Tissue Types
por: Tian, Tian, et al.
Publicado: (2018)

Comprehensive Analysis of the Immune Cell Infiltration Landscape and Immune-Related Methylation in Retinoblastoma
por: Mao, Peiyao, et al.
Publicado: (2022)

Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer
por: Zaravinos, Apostolos, et al.
Publicado: (2019)

Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer
por: Cachot, Amélie, et al.
Publicado: (2021)

Comprehensive Landscape of RRM2 with Immune Infiltration in Pan-Cancer
por: Zhou, Zijian, et al.
Publicado: (2022)

Understanding the immune response and the current landscape of immunotherapy in pancreatic cancer
por: Ostios-Garcia, Lorena, et al.
Publicado: (2021)

5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges
por: Harada, Yoshinori, et al.
Publicado: (2022)

A first or dominant immunization. I. Suppression of simultaneous cytolytic T cell responses to unrelated alloantigens
Publicado: (1993)

Cytolytic activity score as a biomarker for antitumor immunity and clinical outcome in patients with gastric cancer
por: Hu, Qingjiang, et al.
Publicado: (2021)

Towards a Comprehensive Understanding of Human Norovirus Immunity
por: Tomov, Vesselin
Publicado: (2020)

Significance of a preoperative systemic immune-inflammation index as a predictor of postoperative survival outcomes in gastric cancer
por: Inoue, Hiroyuki, et al.
Publicado: (2021)

Late recurrence of breast cancer is associated with pro-cancerous immune microenvironment in the primary tumor
por: Takeshita, Takashi, et al.
Publicado: (2019)

APOBEC3-Mediated RNA Editing in Breast Cancer is Associated with Heightened Immune Activity and Improved Survival
por: Asaoka, Mariko, et al.
Publicado: (2019)

Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential
por: Aoki, Masayo, et al.
Publicado: (2016)

Comprehensive Landscape of Immune Infiltration and Aberrant Pathway Activation in Ischemic Stroke
por: Liu, Rongrong, et al.
Publicado: (2022)

Dissecting the immune cell landscape in hepatocellular carcinoma—are we understanding complexity?
por: Ocker, Matthias
Publicado: (2020)

The current understanding of the immune landscape relative to radiotherapy across tumor types
por: Iliadi, Chrysanthi, et al.
Publicado: (2023)

Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease
por: Buggert, Marcus, et al.
Publicado: (2018)

Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse
por: Lee, Jeansun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3gfl31682usu90sgbl988fssle