Complementary Targeting of Rb Phosphorylation and Growth in Cervical Cancer Cell Cultures and a Xenograft Mouse Model by SHetA2 and Palbociclib

Cervical cancer is caused by high-risk human papillomavirus (HPV) types and treated with conventional chemotherapy with surgery and/or radiation. HPV E6 and E7 proteins increase phosphorylation of retinoblastoma (Rb) by cyclin D1/cyclin dependent kinase (CDK)4/6 complexes. We hypothesized that cycli...

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Detalles Bibliográficos
Autores principales: Kennedy, Amy L., Rai, Rajani, Isingizwe, Zitha Redempta, Zhao, Yan Daniel, Lightfoot, Stanley A., Benbrook, Doris M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281234/
https://www.ncbi.nlm.nih.gov/pubmed/32429557
http://dx.doi.org/10.3390/cancers12051269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281234/
https://www.ncbi.nlm.nih.gov/pubmed/32429557
http://dx.doi.org/10.3390/cancers12051269

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