Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner

Melanoma is the most aggressive skin cancer with an extremely challenging therapy. The dermal-epidermal junction (DEJ) degradation and subsequent dermal invasion are the earliest steps of melanoma dissemination, but the mechanisms remain elusive. We previously identified Tspan8 as a key actor in mel...

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Detalles Bibliográficos
Autores principales: El Kharbili, Manale, Cario, Muriel, Béchetoille, Nicolas, Pain, Catherine, Boucheix, Claude, Degoul, Françoise, Masse, Ingrid, Berthier-Vergnes, Odile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281247/
https://www.ncbi.nlm.nih.gov/pubmed/32455575
http://dx.doi.org/10.3390/cancers12051297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281247/
https://www.ncbi.nlm.nih.gov/pubmed/32455575
http://dx.doi.org/10.3390/cancers12051297

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