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Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner

Melanoma is the most aggressive skin cancer with an extremely challenging therapy. The dermal-epidermal junction (DEJ) degradation and subsequent dermal invasion are the earliest steps of melanoma dissemination, but the mechanisms remain elusive. We previously identified Tspan8 as a key actor in mel...

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Detalles Bibliográficos
Autores principales:	El Kharbili, Manale, Cario, Muriel, Béchetoille, Nicolas, Pain, Catherine, Boucheix, Claude, Degoul, Françoise, Masse, Ingrid, Berthier-Vergnes, Odile
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281247/ https://www.ncbi.nlm.nih.gov/pubmed/32455575 http://dx.doi.org/10.3390/cancers12051297

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