Design, Synthesis, and Biological Evaluation of 1,2,3-Triazole-linked triazino[5,6-b]indole-benzene sulfonamide Conjugates as Potent Carbonic Anhydrase I, II, IX, and XIII Inhibitors

A series of 1,2,3-triazole-linked triazino[5,6-b]indole-benzene sulfonamide hybrids (6a–6o) was synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activity against the human (h) isoforms hCA I, II, XIII (cytosolic isoforms), and hCA IX (transmembrane tumor-associated isofor...

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Detalles Bibliográficos
Autores principales: Chinchilli, Krishna Kartheek, Angeli, Andrea, Thacker, Pavitra S., Korra, Laxman Naik, Biswas, Rashmita, Arifuddin, Mohammed, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281265/
https://www.ncbi.nlm.nih.gov/pubmed/32429261
http://dx.doi.org/10.3390/metabo10050200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281265/
https://www.ncbi.nlm.nih.gov/pubmed/32429261
http://dx.doi.org/10.3390/metabo10050200

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