ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms

Background: High risk neuroblastoma (HR-NB) is one the most difficult childhood cancers to cure. These tumours frequently present with DNA damage response (DDR) defects including loss or mutation of key DDR genes, oncogene-induced replication stress (RS) and cell cycle checkpoint dysfunction. Aim: T...

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Detalles Bibliográficos
Autores principales: Southgate, Harriet E. D., Chen, Lindi, Tweddle, Deborah A., Curtin, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281288/
https://www.ncbi.nlm.nih.gov/pubmed/32354033
http://dx.doi.org/10.3390/cancers12051095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281288/
https://www.ncbi.nlm.nih.gov/pubmed/32354033
http://dx.doi.org/10.3390/cancers12051095

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