Exploring Kinase Inhibition Properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine Derivatives

We previously highlighted the interest in 6,5,6-fused tricyclic analogues of 4-aminoquinazolines as kinase inhibitors in the micromolar to the nanomolar range of IC(50) values. For the generation of chemical libraries, the formamide-mediated cyclization of the cyanoamidine precursors was carried out...

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Detalles Bibliográficos
Autores principales: Loidreau, Yvonnick, Dubouilh-Benard, Carole, Nourrisson, Marie-Renée, Loaëc, Nadège, Meijer, Laurent, Besson, Thierry, Marchand, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281298/
https://www.ncbi.nlm.nih.gov/pubmed/32397570
http://dx.doi.org/10.3390/ph13050089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281298/
https://www.ncbi.nlm.nih.gov/pubmed/32397570
http://dx.doi.org/10.3390/ph13050089

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